Hexamethylene bisacetamide (HMBA) is a potent inducer of cell differentiation and HIV production in chronically infected cells.However, its mechanism of action remains poorly defined.In this study, we demonstrate that HMBA activates transiently the PI3K/Akt pathway, which leads to the phosphorylation of HEXIM1 and the subsequent release of active p
Objective: To analyse variations in axial length (AL), corneal radius (CR) and the AL/CR ratio over one year in eight-year-old schoolchildren, considering sex, ethnicity and refractive error.Methods: Vision screenings were conducted in 16 schools in Terrassa (Barcelona, Spain) with eight-year-old children as part of the CISViT project.Measurements
Epithelial-to-mesenchymal winnipeg parks shrub rose transition (EMT), a well-established phenomenon studied across pan-cancer types, has long been known to be a major player in driving tumor invasion and metastasis.Recent studies have highlighted the importance of partial EMT phenotypes in metastasis.Initially thought as a transitional state betwee
To elucidate the interspecies connectivity between cyanobacteria and other bacteria (non-cyanobacteria) during cyanobacterial harmful algal blooms (cyanoHABs), samples were collected from the Nakdong River, Korea, from June 2016 to August 2017, and microbial recurrent association network (MRAN) analysis was performed to overcome the limitations of
During the last fifty years ecology has matured as a scientific discipline.In this paper I analyse the temporal development of the paradigm based on physical systems (the ecosystem paradigm), and the evolutionary ecology paradigm.I first analyse the contents of 61 textbooks to calculate the relative importance of ecosystem and evolutionary ecology